I answered this question on the Matrix forum with the following solution:
In addition, when you're stuck in the game and can't navigate out, use the Windows Task Manager to close the game - Ctrl+Alt+Del, select 'Start Task Manager', select Tab 'Applications', find NSD game running and select it, then select 'End Task'I had the same issue as my HDTV serves as my monitor. Real easy to fix by opening the SOWWL.ini file found in Documents/SowWL. Change the screen resolution from =100 to =0. This will set the game to the default 1024x768. Then you can experiment with the other resolutions to see what works best for you. Of the larger resolutions I find that 2080x1024 works best for my setup. I use this for both my HDTV (while playing game) and game.